Oxford Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it tries to restore itself to normal before the harm was achieved. Satterwhite Chiropractic is never shocked at what the body can do! Satterwhite Chiropractic sees its Oxford chiropractic care as a partner of the body’s system in healing especially when there is spine pain. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is proving value by interrupting the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process during which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin boosted autophagy and decreased the degradation of the disc’s extracellular matrix (technically indicated by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Satterwhite Chiropractic is inspired by this research to see just how well melatonin can work for Oxford back pain linked to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is quite a common condition seen at Satterwhite Chiropractic making positive news like this quite exciting. A new study described that melatonin could modulate the extracellular matrix of the disc remodeling process initiated by IL-1 β. Further, melatonin decreased the inflammatory cell collection and reduced the release of linked inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin interrupted the IL-1B feedback loop, researchers proposed that melatonin may contribute to the restoration process of intervertebral discs after damage has already been done. (1) Satterwhite Chiropractic will keep following the new research on the role inflammation plays in Oxford disc degeneration and melatonin’s role in combatting it.
INFLAMMATION AND MELATONIN
The importance of melatonin in assisting to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite appropriate. It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific effect on inflammation and disc degeneration is most interesting to Satterwhite Chiropractic and our Oxford back pain patients.
CONTACT Satterwhite Chiropractic
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she illustrates how The Cox® Technic System of Spinal Pain Management manages disc degeneration for relief of chronic low back pain in her patient.
Schedule your Oxford chiropractic appointment with Satterwhite Chiropractic now. We can discuss the role inflammation plays in your back pain experience and how melatonin may help with the related disc degeneration.
